Advancements in Extrusion-Spheronization. More agile techniques are improving the development of multiparticulate drug-delivery systems. Caleva Process Solutions Another resourceful Powerpoint Presentation from Caleva Process Solutions. These selection. Extrusion – to form rod shaped particles of uniform diameter. Spheronization – to round off these rods into spherical particles. Drying – to.

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Even if the ball-shaped extrudate is imperfect, the evenness of the surface still creates good conditions for subsequent coating. Application of Multiparticulate Technologies for Drug Delivery.

The process consists of five operations. For many pharmaceutical applications, extruded pellets are achieved in suitable quality if a sufficient portion of microcrystalline cellulose is added.

Overview of the Extrusion-Spheronization Process

The coated spheres may be used for encapsulation, compression, or direct packaging into sachets or pouches for extrysion. In the pharmaceutical industry, pellets of medium particle sizes from to 2, micrometers are used for most applications. This dough then pressed through an extruder. Capsugel is well versed in using drug layering and modified-release coat layering to achieve a range of dissolution profiles in multiparticulate format.

By Product Development Site. The diameter of the openings in the extrusion plate or extrusion basket determines the strength of the elongated extrusion threads that result. In other industries, the size of the pellets can be several centimeters. Extursion clicking “I Agree”, you confirm that you are above the age of 16, that you have read and understood the Privacy Policy and spherojization Cookies Policy, and that you agree to the collection, use and processing of your Personal Information by Lonza in accordance with said policies.


The Extrusion Spheronization Processs

Cookies spheronuzation us to give you the best browsing experience and help us to understand how you use our site. Capsugel offers a drug delivery technology to provide oral delivery with full enteric protection and rapid release in the upper gastrointestinal GI tract without the use of coatings.

Just the way you need it. Agglomeration through extrusion and spheronization is one of the oldest techniques for manufacturing pellets. Common applications include delayed release, extended release, pulsatile release, and fixed dose combinations. Register for An Account Already a member? Primary packaging in either vials or sachets and secondary packaging services are also available. For technical reasons, the resulting pellets are larger than micrometers.

Join us for the multiparticulates webinar, where key considerations in designing multiparticulate formulations and processing will be discussed with representative case studies.

Extrusion / Spheronization – Glatt Integrated Process Solutions

The ratio of liquid to solid material together with the size of the extruder holes significantly determines the quality of the extrudates. Moistening the powder mixture, forming cylinder-shaped agglomerate through extrusion, breaking and rounding the extrudate to round pellets through spheronization, and drying the finished product.

The spheres may undergo additional processing steps to apply functional or cosmetic coatings using fluid bed processing with a Wurster insert. The process consists of four process steps: It is useful for making dense granules for controlled-release solid oral dosage forms with a minimum amount of excipients, as well as multiparticulates used for immediate, modified, or sustained-release. The wet mass is added into an LCI Multigranulator MG 55 where it is forced through a specific screen to form cylindrical extrudates using either dome, radial or axial extrusion for process optimization.


By continuing to use this website, you agree that we may store and access cookies on your device. The final drying ensures the pellet hardness. By visiting our website or using services provided by Lonza, you are accepting the practices described in the Privacy Policy. We also use cookies on our websites. Please note that Lonza has updated its Privacy Policy.

The resultant spheres are dried in a fluid bed dryer and particle size is selected by sieve cuts.

Capsugel has extensive experience in designing, formulating and scaling mulitparticulate dosage forms at feasibility, pilot and commercial scales. The wet extrudate is added to an LCI Marumerizer QJT spheronizer equipped with a high speed spinning plate which forms spheroniation spheres from the extrudate “rope”. Read more about it here!

The dry, mixed, sphernoization active substances are kneaded into a dough with a liquid. Capsugel has extensive experience and capabilities in optimizing pediatric and multiparticulate formulations. Please read our updated Cookies Policy for information about which cookies we use and the information we collect.

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Capsugel Dosage Form Solutions is offering a webinar that provides an overview of current taste masking approaches, with emphasis on two growing technology options. The technology chosen is dependent upon multiple active ingredient and formulation criteria, e. Our Mini-tablets are a popular finished dosage form presentation and offers the benefits of multiparticulates while using established tableting technology.

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