Perthes disease, also known as Legg-Calvé-Perthes disease, refers to idiopathic osteonecrosis of the femoral epiphysis seen in children. It should not be.

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Disorders of hemostasis in childhood: Mayo Clinic does not endorse companies or products. The Kinston antiphospholipid group. Request an Appointment at Mayo Clinic. Osteonecrosis generally occurs secondary to abnormal or damaged blood supply to the femoral epiphysis, leading to fragmentation, bone loss, and eventual structural collapse of the femoral head.

This content does not have an Arabic version. Mayo Foundation for Medical Education and Research; Perthes is a form of osteochondritis which only affects the hip, although dw forms of osteochondritis can affect elbows, knees, ankles, and feet. N Engl J Med,pp. Decreased fibrynolitic potential in patients with idio-pathic avascular necrosis and transient osteoporosis of the hip. Options include traction to separate the femur from the pelvis and reduce wearbraces often for several months, with an average of 18 months to restore perthew of motion, physiotherapyand surgical intervention when necessary because of permanent joint damage.

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Approach to hip pain in childhood. Results Alterations in hemostasis and thrombosis were detectedin one patient who had moderate-to-light protein Sdeficiency.

Legg–Calvé–Perthes disease

Essentials of Skeletal Radiology. High risk of thrombosis in patients homozigous for factor V Leiden activated protein C resistance.


The ball femoral head enferrmedad at the top of the thighbone femur and the socket acetabulum is part of the hip bone. Clin Chem, 32pp. Mutation in gene coding for factor V and the risk of myocardial infarction, stroke and venous thrombosis in apparently healthy men. As changes progress, the width of the femoral neck increases coxa magna in order to increase weight-bearing support.

Physiotherapy generally involves a series of daily exercises, with weekly meetings with a physiotherapist to monitor progress. Clin Orthop,pp. Legg-Calve-Perthes disease occurs when too little blood is supplied to the ball portion of the hip joint femoral head. Blood, 82pp.

Maturation of the hemostatic system during childhood. The lifetime risk of a child developing the disease is about one per 1, individuals.

Enfermedad de Legg-Calvé-Perthes – Síntomas y causas – Mayo Clinic

The remaining patients were considered withinthe normal range when age was enfermsdad into account. Retrieved 28 February A bone scan or MRI may be useful in making the diagnosis in those cases where X-rays are inconclusive. Am J Clin Pathol, 94pp. Case 5 Case 5. Activated protein C resistance as an additional risk factor for thrombosis in protein C deficient families.

Atrophy of thigh muscles may occur from disuse pdrthes an inequality perhes leg length. Relation of altered hemostasis to etiology. Usually, plain radiographic changes are delayed 6 weeks or more from clinical onset, so bone scintigraphy and MRI are done for early diagnosis.

Necesidades del alumnado con diabetes tipo 1 en Treatment in Perthes disease is largely related to symptom control, particularly in the early phase of the disease. Map of IPSG providers.


Swimming is highly recommended, as it allows exercise of the hip muscles with full range of motion while reducing the stress to a minimum. Case 6 Case 6. Advertising revenue supports our not-for-profit mission.

Background It has been suggested that the cause of Perthes diseasemay be intravascular thrombosis induced by a potentialcongenital hemostatic disorder leading to conditions ofthrombophilia or hyperfibrinolysis. The complete process of bone death, fracture and renewal can take several years. Ferri’s Clinical Advisor Am J Hematol, pertbespp. Some children have a coincidental history of trauma. Bilateral Perthes, which means both hips are affected, should always be investigated thoroughly to rule out multiple epiphyseal dysplasia.

Mayo Clinic Marketplace Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. It is important to be certain that there is no other cause of osteonecrosis e. Hip and joint ee The hip joint is a ball-and-socket joint. Thromb Res, 11pp. This will minimize the long-term effects of the disease. Accessed March 19, Mutation in blood coagulation factor V associated with resistance to activated protein C. Mayo Clinic, Rochester, Minn. Pain is usually mild. The aim of therapy is to try and maintain good femoroacetabular contact and a round femoral head.