Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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The amount and thickness of the elastic fibers in the papillary dermis had increased markedly.

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Our website uses cookies to enhance your experience. The fibers in the papillary layer are thickened, arranged vertically and penetrate into the serpigionsa, where they form characteristic narrow tunnels with a right, wave or spiral arrangement.

Author information Article notes Copyright and License information Disclaimer. Multiple therapies have been reported to be effective in the management of EPS.

Elastosis perforans serpiginosa | DermNet NZ

A case of elastosis perforans serpiginosa. How to cite this URL: Related articles D-penicillamine elastosis perforans serpiginosa lumpy-bumpy elastic fibers.

serpiginoaa Increased elastic tissue and solar elastotic syndromes. Characteristic for EPS skin lesions within face A and left upper extremity B, C — papular keratotic lesions fuced together in serpiginous arrangement.

The diagnosis of elastosis perforans serpiginosa is made by its clinical appearance and by the characteristic histology changes seen on skin biopsyshowing transepidermal elimination of elastic tissue.

Cryotherapy was tried a few more serpjginosa, also without improvement, and the patient was finally re-treated with tazarotene, which flattened her lesions within 6 weeks. Hofmann et al 4 reported tazarotene’s effectiveness in the treatment of congenital ichthyoses in an open, intraindividually controlled, half-side investigation. Although lesions may spontaneously resolve, they often persist for longer periods. Response of elastosis perforans serpiginosa to pulsed CO2, Er: Tazarotene may have comedolytic properties that allow for the unplugging of transepidermal pores in this disease.


Elastosis Perforans Serpiginosa

Table 1 summarizes the clinical data from four cases of EPS in the Korean literature in addition to our case. Published online Oct Purchase access Subscribe to the journal.

Numerous treatment modalities have been described, including dry ice 8cellophane tape stripping 813electrodessication and curettage 14cryotherapy 13 – 15intralesional and topical corticosteroid therapy 1516topical calcipotriol 14topical tretinoin 141517oral isotretinoin 1415topical tazarotene 15topical imiquimod 18topical glycolic or salicylic acid therapy 1417narrow band ultraviolet B radiation 14pulsed dye laser, Er: Four types of elastosis perforans serpiginosa EPS have been described in literature: Disorders of transepidermal elimination.

Verhoeff-van Gieson staining showed a markedly increased number of altered seripginosa fibers forming dense clumps in the upper dermis Fig. Since it was first described by Lutz inEPS is one of four classic primary perforating disorders along with reactive perforating perfoorans, perforating folliculitis, and Kyrle disease 1. Patient 2 then discontinued tazarotene therapy, and her disease flared. A year-old woman presented with a 2-year history of an eruption on the anterior aspect of her neck and right arm that was relatively asymptomatic.

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A biopsy specimen demonstrated a central focus of pseudoepitheliomatous hyperplasia that appeared to be connected to serpiginoss epidermis by a channel of epithelium.


Elastosis perforans serpiginosa

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EPS is more commonly reported in men and usually occurs during childhood or early adulthood 1. Familial elastosis perforans serpiginosa. However, it remains unclear whether the relationship between these conditions and EPS is causal or coincidental, as EPS also commonly occurs in individuals without any underlying disease.

Many conditions are associated with EPS, including Down syndrome, Rothmund-Thomson ssrpiginosa, Ehler-Danlos syndrome, Marfan syndrome, osteogenesis imperfecta, and pseudoxanthoma elasticum.

We can distinguish three subtypes of EPS. The middle of each lesion is umbilicated from which the material containing damaged elastic swrpiginosa is extruded [ 12 ]. The skin at the entrance of the tunnel accumulates chronic inflammatory infiltrate composed often of giant cells [ 1112 ].

However, the irritation subsided after a few weeks of therapy. In this case, EPS coexisted with plaque psoriasis, however manipulations did not provoke psoriatic papules in this region, while evoked EPS lesions. The biopsy specimen demonstrated clawlike downgrowths of epidermis surrounding collections of amorphous basophilic debris and hyperplastic elastic fibers.

The first description elastosiis EPS was most likely published in Fisherand at that time, because of the clinical presentation, this condition was classified into a group of diseases with hyperkeratosis.