This book originated from a series of papers which were published in “Die Naturwissenschaften” in Its division into three parts is the reflection of a . It is suggested that the concept of a hypercycle should be formally M. Eigen. Naturwissenschaften, 58 (), p. Eigen et al., “more RNA in replicators”. BOTH. FIRST more replicators: ecosystem based solution. Hypercycles (Eigen’s original solution). Emergence of higher levels of.

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Several researchers proposed a solution to these problems by introducing space into the initial model either explicitly [6] [13] [47] [48] or in the form of a spatial segregation within compartments.

The primary of them was that the formation of hypercycles had required the availability of both types of chains: Computational and Mathematical Methods in Medicine.

As a consequence, the catalysed replication could exceed the uncatalysed reactions, and the system could grow faster.

Hypercycle (chemistry) – Wikipedia

The hypercycle concept has been continuously studied since its origin. At the time of the hypercycle theory formulation, enzymatic properties were attributed only to proteinswhile nucleic acids were recognized only as carriers of information. He also underlined hypercycle vulnerability to parasites, as they are favoured by selection. Over the years, the hypercycle hypercjcle has experienced many reformulations and methodological approaches.

The idea is that these hypercycles would build up by mutation and natural selection all of the substances and ultimately the processes and structures of living cells. Nowadays, taking into account the knowledge about ribozymes, it may be possible that a hypercycle’s members were selected from the quasispecies population and the enzymatic function was performed by RNA.

However, it was recently shown that those limitations could in principle be htpercycle by the assembly of active polymerase ribozymes from several short RNA strands. Spiral Waves as a Substrate for Prebiotic Evolution”. They are hypothetical non-biological autocatalytic chemical reaction cycles of the substances thought to be needed for the spontaneous generation of life.


Hypercycle – CreationWiki, the encyclopedia of creation science

Usually, even large fluctuations in the numbers of internal species cannot weaken the hypercycle enough to destroy it. Carsten Bresch and coworkers raised an objection that hypercyclic organization is not necessary if compartments are taken into account.

Some genotypes could introduce cooperation by recognizing target sequences of the other ribozymes, promoting their covalent bindingwhile other selfish digen were only able to self-assemble.

This observation was the motivation for the formulation of the hypercycle theory. Hypercycle elements should be simultaneously catalysts enzymes and replicators. The Stochastic Corrector Model vs. Secondly, it keeps the effect of mutations local, while at the same time affecting the whole compartment. Both compartmentalized systems proved to be robust against parasites.

After that, the whole individualized and compartmentalized hypercycle can behave like a simple self-replicating entity. In this way, the existence of similar sequences I originating from the same quasispecies population promotes the creation of the linkage between molecules I and I.

This can be a solution to the error threshold problem, which states that, in a system without ideal replicationan excess of mutation events would destroy the ability to carry information and hyperxycle the creation of larger and fitter macromolecules. Without this feedback loop, the replicating system would be lost.


Nowadays, it is assumed that the hypercycle model could be realized by utilization of ribozymes without the need egen a hypercycle with translation, and there are many more theories about the origin of the genetic code. This makes them still nothing more than mere speculation and, while the hypothesis has been a recurring theme in the scientific literature about the origin of life, it is not frequently mentioned anymore in recent publications in the field.

In other projects Wikimedia Commons. Such a concept, apart from an increased information capacity, has another advantage. Artificial Intelligence in Medicine. The cyclic organization of the hypercycle ensures its structure stability. According to the hypercycle theory, the first primitive polymerase emerged precisely from this population.


Parasitic branches are species coupled to a cycle that do not provide any advantage to the reproduction of a cycle, which, in turn, makes them useless and decreases the selective value of the system. One possibility of linking different chains I —which is relatively easy to achieve taking into account the quasispecies properties—is that the one chain I improves the synthesis of the similar chain I.

Schuster consider hypercycles as predecessors of protocells primitive unicellular biological organisms [1]. The hypercycle model was a highly speculative schema proposed by Nobel Prize in chemistry, Manfred Eigen along with his graduate student Peter Schuster.

One such alternative was a model with one replicase that performed polymerase functionality and that was a translational product of one of the RNA matrices existing among the quasispecies. Retrieved from ” http: This vicious circle is known as Eigen’s Paradox. Hypercycles are just another in the long line of Evolutionary just so stories that are invented to try to explain the origin of life by natural processes.

Nature and Evolution of Early Replicons”.

Unfortunately, in this case, rotation decelerates as the number of hypercycle members increases, meaning that selection tends toward decreasing the amount of information stored in the hypercycle. Discovery of ribozyme catalytic properties [16] [17]. In order to be preserved, the new information has to appear near to the core of the spiral wave.

Thus, the total concentration of molecules x i 0 and y i 0 will be the sum of free molecules and molecules involved in a complex:.

Experimental demonstration that ribozymes can form collectively autocatalytic sets [15].