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Argatroban | Intravenous Infusion | Direct Thrombin Inhibitors
This patient had a documented history of an allergic reaction to heparin, and we chose to use Argatroban for CPB to avoid a potential allergic reaction, although the allergy testing for porcine heparin was negative. Preoperative consultation by the allergologist was obtained and the patient underwent allergy testing for porcine heparin, which was negative. Where can I go for care during the holidays?
Bleeding post CPB was corrected with administration of appropriate blood products. The use of Argatroban for cardiopulmonary bypass remains off label and the subject of a few case reports. Oxford University Press is a department of the University of Oxford.
Critical Care Trauma Centre. No Smoking on Hospital Property. The patient was successfully weaned off cardiopulmonary bypass, with the Argatroban being stopped once cardiac activity had recommenced and the aortic cross-clamp had been removed. Around Europe You can find specific information on our products in individual countries by choosing the relevant country from the menu below: Rewarming was commenced and the proximal anastomosis was performed.
This site is intended for Healthcare Professionals in specific European countries where argatroban is licensed. Door op “doorgaan” hieronder te klikken, verklaart u dat u een ingezetene bent van Nederland en dat u de gebruiksvoorwaarden van deze website aanvaardt.
Argatroban is given as a continuous intravenous infusion. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Use with caution in patients concomitantly receiving other anticoagulants or antiplatelet agents, or at increased risk of hemorrhage eg.
Entire mitral valve reconstruction using porcine extracellular matrix: Consideration is also being given to utilizing Argatroban in the CPB circuit in case we need to return to cardiopulmonary bypass.
Can thromboelastography predict which patients with heparin-induced thrombocytopenia may suffer thrombotic complications of type II? A subcutaneous fluid collection after the Bentall procedure in a female informatiom with giant cell arteritis. CPBAnticoagulationMitral valve replacement. The CPB circuit utilized non-heparin bonded non-coated tubing, and a cell saver reservoir was spliced into the CPB circuit as a cardiotomy reservoir.
Initial dose by continuous infusion: After institution of CPB, cardiac arrest was achieved by warm antegrade cardioplegia given via the aortic root, and then cold cardioplegia given via the coronary sinus. Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery.
However, this may delay the achievement of adequate hemostasis prior to closing. The successful outcome of this case supports the use of Argatroban as an alternative to heparin for anticoagulation in Aragtroban in patients with a contraindication to heparin administration.
There was no neurological injury, and he was extubated on the operative night. Study reveals clinical factors linked to reduced mortality in injection drug users with heart valve infection. The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations.
Latest Most Read Most Cited Intraoperative, open-heart coronary angiography in severe acute aortic valve endocarditis. More on this topic Perioperative thrombocytopenia in cardiac surgical patients — incidence of heparin-induced thrombocytopenia, morbidities and mortality.
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There are a few reported cases in the literature of its use as an anticoagulant in patients with HIT undergoing cardiopulmonary bypass for cardiac surgery [1—3].
ARGATROBAN | LHSC
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Postoperatively the patient did well. Its use as an anticoagulant for cardiopulmonary bypass remains off-label.